Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart
Identifieur interne : 000828 ( Main/Exploration ); précédent : 000827; suivant : 000829Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart
Auteurs : Maryam Oroujeni [Suède] ; Ayman Abouzayed [Suède] ; Fanny Lundmark [Suède] ; Bogdan Mitran [Suède] ; Anna Orlova [Suède] ; Vladimir Tolmachev [Suède] ; Ulrika Rosenström [Suède]Source :
- Pharmaceutics [ 1999-4923 ] ; 2019.
Abstract
Radiolabelled antagonistic bombesin analogues are successfully used for targeting of gastrin-releasing peptide receptors (GRPR) that are overexpressed in prostate cancer. Internalization of antagonistic bombesin analogues is slow. We hypothesized that the use of a non-residualizing radioiodine label might not affect the tumour uptake but would reduce the retention in normal organs, where radiopharmaceutical would be internalized. To test this hypothesis, tyrosine was conjugated via diethylene glycol linker to N-terminus of an antagonistic bombesin analogue RM26 to form Tyr-PEG2-RM26. [111In]In-DOTA-PEG2-RM26 was used as a control with a residualizing label. Tyr-PEG2-RM26 was labelled with 125I with 95% radiochemical purity and retained binding specificity to GRPR. The IC50 values for Tyr-PEG2-RM26 and DOTA-PEG2-RM26 were 1.7 ± 0.3 nM and 3.3 ± 0.5 nM, respectively. The cellular processing of [125I]I-Tyr-PEG2-RM26 by PC-3 cells showed unusually fast internalization. Biodistribution showed that uptake in pancreas and tumour was GRPR-specific for both radioconjugates. Blood clearance of [125I]I-Tyr-PEG2-RM26 was appreciably slower and activity accumulation in all organs was significantly higher than for [111In]In-DOTA-PEG2-RM26. Tumor uptake of [111In]In-DOTA-PEG2-RM26 was significantly higher than for [125I]I-Tyr-PEG2-RM26, resulting in higher tumour-to-organ ratio for [111In]In-DOTA-PEG2-RM26 at studied time points. Incorporation of amino acids with hydrophilic side-chains next to tyrosine might overcome the problems associated with the use of tyrosine as a prosthetic group for radioiodination.
Url:
DOI: 10.3390/pharmaceutics11080380
PubMed: 31382362
PubMed Central: 6724035
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000793
- to stream Pmc, to step Curation: 000793
- to stream Pmc, to step Checkpoint: 000769
- to stream Ncbi, to step Merge: 000883
- to stream Ncbi, to step Curation: 000883
- to stream Ncbi, to step Checkpoint: 000883
- to stream Main, to step Merge: 000828
- to stream Main, to step Curation: 000828
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart</title><author><name sortKey="Oroujeni, Maryam" sort="Oroujeni, Maryam" uniqKey="Oroujeni M" first="Maryam" last="Oroujeni">Maryam Oroujeni</name><affiliation wicri:level="4"><nlm:aff id="af1-pharmaceutics-11-00380">Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Abouzayed, Ayman" sort="Abouzayed, Ayman" uniqKey="Abouzayed A" first="Ayman" last="Abouzayed">Ayman Abouzayed</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lundmark, Fanny" sort="Lundmark, Fanny" uniqKey="Lundmark F" first="Fanny" last="Lundmark">Fanny Lundmark</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Mitran, Bogdan" sort="Mitran, Bogdan" uniqKey="Mitran B" first="Bogdan" last="Mitran">Bogdan Mitran</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Orlova, Anna" sort="Orlova, Anna" uniqKey="Orlova A" first="Anna" last="Orlova">Anna Orlova</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af3-pharmaceutics-11-00380">Science for Life Laboratory, Uppsala University, SE-750 03 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, SE-750 03 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Tolmachev, Vladimir" sort="Tolmachev, Vladimir" uniqKey="Tolmachev V" first="Vladimir" last="Tolmachev">Vladimir Tolmachev</name><affiliation wicri:level="4"><nlm:aff id="af1-pharmaceutics-11-00380">Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Rosenstrom, Ulrika" sort="Rosenstrom, Ulrika" uniqKey="Rosenstrom U" first="Ulrika" last="Rosenström">Ulrika Rosenström</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31382362</idno><idno type="pmc">6724035</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724035</idno><idno type="RBID">PMC:6724035</idno><idno type="doi">10.3390/pharmaceutics11080380</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000793</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000793</idno><idno type="wicri:Area/Pmc/Curation">000793</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000793</idno><idno type="wicri:Area/Pmc/Checkpoint">000769</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000769</idno><idno type="wicri:Area/Ncbi/Merge">000883</idno><idno type="wicri:Area/Ncbi/Curation">000883</idno><idno type="wicri:Area/Ncbi/Checkpoint">000883</idno><idno type="wicri:Area/Main/Merge">000828</idno><idno type="wicri:Area/Main/Curation">000828</idno><idno type="wicri:Area/Main/Exploration">000828</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart</title><author><name sortKey="Oroujeni, Maryam" sort="Oroujeni, Maryam" uniqKey="Oroujeni M" first="Maryam" last="Oroujeni">Maryam Oroujeni</name><affiliation wicri:level="4"><nlm:aff id="af1-pharmaceutics-11-00380">Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Abouzayed, Ayman" sort="Abouzayed, Ayman" uniqKey="Abouzayed A" first="Ayman" last="Abouzayed">Ayman Abouzayed</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lundmark, Fanny" sort="Lundmark, Fanny" uniqKey="Lundmark F" first="Fanny" last="Lundmark">Fanny Lundmark</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Mitran, Bogdan" sort="Mitran, Bogdan" uniqKey="Mitran B" first="Bogdan" last="Mitran">Bogdan Mitran</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Orlova, Anna" sort="Orlova, Anna" uniqKey="Orlova A" first="Anna" last="Orlova">Anna Orlova</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="af3-pharmaceutics-11-00380">Science for Life Laboratory, Uppsala University, SE-750 03 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Uppsala University, SE-750 03 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Tolmachev, Vladimir" sort="Tolmachev, Vladimir" uniqKey="Tolmachev V" first="Vladimir" last="Tolmachev">Vladimir Tolmachev</name><affiliation wicri:level="4"><nlm:aff id="af1-pharmaceutics-11-00380">Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Rosenstrom, Ulrika" sort="Rosenstrom, Ulrika" uniqKey="Rosenstrom U" first="Ulrika" last="Rosenström">Ulrika Rosenström</name><affiliation wicri:level="4"><nlm:aff id="af2-pharmaceutics-11-00380">Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicinal Chemistry, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author></analytic><series><title level="j">Pharmaceutics</title><idno type="eISSN">1999-4923</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Radiolabelled antagonistic bombesin analogues are successfully used for targeting of gastrin-releasing peptide receptors (GRPR) that are overexpressed in prostate cancer. Internalization of antagonistic bombesin analogues is slow. We hypothesized that the use of a non-residualizing radioiodine label might not affect the tumour uptake but would reduce the retention in normal organs, where radiopharmaceutical would be internalized. To test this hypothesis, tyrosine was conjugated via diethylene glycol linker to N-terminus of an antagonistic bombesin analogue RM26 to form Tyr-PEG<sub>2</sub>-RM26. [<sup>111</sup>In]In-DOTA-PEG<sub>2</sub>-RM26 was used as a control with a residualizing label. Tyr-PEG<sub>2</sub>-RM26 was labelled with <sup>125</sup>I with 95% radiochemical purity and retained binding specificity to GRPR. The IC<sub>50</sub> values for Tyr-PEG<sub>2</sub>-RM26 and DOTA-PEG<sub>2</sub>-RM26 were 1.7 ± 0.3 nM and 3.3 ± 0.5 nM, respectively. The cellular processing of [<sup>125</sup>I]I-Tyr-PEG<sub>2</sub>-RM26 by PC-3 cells showed unusually fast internalization. Biodistribution showed that uptake in pancreas and tumour was GRPR-specific for both radioconjugates. Blood clearance of [<sup>125</sup>I]I-Tyr-PEG<sub>2</sub>-RM26 was appreciably slower and activity accumulation in all organs was significantly higher than for [<sup>111</sup>In]In-DOTA-PEG<sub>2</sub>-RM26. Tumor uptake of [<sup>111</sup>In]In-DOTA-PEG<sub>2</sub>-RM26 was significantly higher than for [<sup>125</sup>I]I-Tyr-PEG<sub>2</sub>-RM26, resulting in higher tumour-to-organ ratio for [<sup>111</sup>In]In-DOTA-PEG<sub>2</sub>-RM26 at studied time points. Incorporation of amino acids with hydrophilic side-chains next to tyrosine might overcome the problems associated with the use of tyrosine as a prosthetic group for radioiodination.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, R L" uniqKey="Siegel R">R.L. Siegel</name></author><author><name sortKey="Miller, K D" uniqKey="Miller K">K.D. Miller</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A. Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aragon Ching, J B" uniqKey="Aragon Ching J">J.B. Aragon-Ching</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, X" uniqKey="Yuan X">X. Yuan</name></author><author><name sortKey="Cai, C" uniqKey="Cai C">C. Cai</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Yu, Z" uniqKey="Yu Z">Z. Yu</name></author><author><name sortKey="Balk, S P" uniqKey="Balk S">S.P. Balk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emmett, L" uniqKey="Emmett L">L. Emmett</name></author><author><name sortKey="Willowson, K" uniqKey="Willowson K">K. Willowson</name></author><author><name sortKey="Violet, J" uniqKey="Violet J">J. Violet</name></author><author><name sortKey="Shin, J" uniqKey="Shin J">J. Shin</name></author><author><name sortKey="Blanksby, A" uniqKey="Blanksby A">A. Blanksby</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kratochwil, C" uniqKey="Kratochwil C">C. Kratochwil</name></author><author><name sortKey="Bruchertseifer, F" uniqKey="Bruchertseifer F">F. Bruchertseifer</name></author><author><name sortKey="Rathke, H" uniqKey="Rathke H">H. Rathke</name></author><author><name sortKey="Hohenfellner, M" uniqKey="Hohenfellner M">M. Hohenfellner</name></author><author><name sortKey="Giesel, F L" uniqKey="Giesel F">F.L. Giesel</name></author><author><name sortKey="Haberkorn, U" uniqKey="Haberkorn U">U. Haberkorn</name></author><author><name sortKey="Morgenstern, A" uniqKey="Morgenstern A">A. Morgenstern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silver, D A" uniqKey="Silver D">D.A. Silver</name></author><author><name sortKey="Pellicer, I" uniqKey="Pellicer I">I. Pellicer</name></author><author><name sortKey="Fair, W R" uniqKey="Fair W">W.R. Fair</name></author><author><name sortKey="Heston, W D" uniqKey="Heston W">W.D. Heston</name></author><author><name sortKey="Cordon Cardo, C" uniqKey="Cordon Cardo C">C. Cordon-Cardo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spatz, S" uniqKey="Spatz S">S. Spatz</name></author><author><name sortKey="Tolkach, Y" uniqKey="Tolkach Y">Y. Tolkach</name></author><author><name sortKey="Jung, K" uniqKey="Jung K">K. Jung</name></author><author><name sortKey="Stephan, C" uniqKey="Stephan C">C. Stephan</name></author><author><name sortKey="Busch, J" uniqKey="Busch J">J. Busch</name></author><author><name sortKey="Ralla, B" uniqKey="Ralla B">B. Ralla</name></author><author><name sortKey="Rabien, A" uniqKey="Rabien A">A. Rabien</name></author><author><name sortKey="Feldmann, G" uniqKey="Feldmann G">G. Feldmann</name></author><author><name sortKey="Brossart, P" uniqKey="Brossart P">P. Brossart</name></author><author><name sortKey="Bundschuh, R A" uniqKey="Bundschuh R">R.A. Bundschuh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheikhbahaei, S" uniqKey="Sheikhbahaei S">S. Sheikhbahaei</name></author><author><name sortKey="Afshar Oromieh, A" uniqKey="Afshar Oromieh A">A. Afshar-Oromieh</name></author><author><name sortKey="Eiber, M" uniqKey="Eiber M">M. Eiber</name></author><author><name sortKey="Solnes, L B" uniqKey="Solnes L">L.B. Solnes</name></author><author><name sortKey="Javadi, M S" uniqKey="Javadi M">M.S. Javadi</name></author><author><name sortKey="Ross, A E" uniqKey="Ross A">A.E. Ross</name></author><author><name sortKey="Pienta, K J" uniqKey="Pienta K">K.J. Pienta</name></author><author><name sortKey="Allaf, M E" uniqKey="Allaf M">M.E. Allaf</name></author><author><name sortKey="Haberkorn, U" uniqKey="Haberkorn U">U. Haberkorn</name></author><author><name sortKey="Pomper, M G" uniqKey="Pomper M">M.G. Pomper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ananias, H J" uniqKey="Ananias H">H.J. Ananias</name></author><author><name sortKey="Van Den Heuvel, M C" uniqKey="Van Den Heuvel M">M.C. van den Heuvel</name></author><author><name sortKey="Helfrich, W" uniqKey="Helfrich W">W. Helfrich</name></author><author><name sortKey="De Jong, I J" uniqKey="De Jong I">I.J. de Jong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Wiele, C" uniqKey="Van De Wiele C">C. Van de Wiele</name></author><author><name sortKey="Dumont, F" uniqKey="Dumont F">F. Dumont</name></author><author><name sortKey="Vanden Broecke, R" uniqKey="Vanden Broecke R">R. Vanden Broecke</name></author><author><name sortKey="Oosterlinck, W" uniqKey="Oosterlinck W">W. Oosterlinck</name></author><author><name sortKey="Cocquyt, V" uniqKey="Cocquyt V">V. Cocquyt</name></author><author><name sortKey="Serreyn, R" uniqKey="Serreyn R">R. Serreyn</name></author><author><name sortKey="Peers, S" uniqKey="Peers S">S. Peers</name></author><author><name sortKey="Thornback, J" uniqKey="Thornback J">J. Thornback</name></author><author><name sortKey="Slegers, G" uniqKey="Slegers G">G. Slegers</name></author><author><name sortKey="Dierckx, R A" uniqKey="Dierckx R">R.A. Dierckx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jensen, R T" uniqKey="Jensen R">R.T. Jensen</name></author><author><name sortKey="Battey, J F" uniqKey="Battey J">J.F. Battey</name></author><author><name sortKey="Spindel, E R" uniqKey="Spindel E">E.R. Spindel</name></author><author><name sortKey="Benya, R V" uniqKey="Benya R">R.V. Benya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nock, B A" uniqKey="Nock B">B.A. Nock</name></author><author><name sortKey="Nikolopoulou, A" uniqKey="Nikolopoulou A">A. Nikolopoulou</name></author><author><name sortKey="Galanis, A" uniqKey="Galanis A">A. Galanis</name></author><author><name sortKey="Cordopatis, P" uniqKey="Cordopatis P">P. Cordopatis</name></author><author><name sortKey="Waser, B" uniqKey="Waser B">B. Waser</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author><author><name sortKey="Maina, T" uniqKey="Maina T">T. Maina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Cai, W" uniqKey="Cai W">W. Cai</name></author><author><name sortKey="Cao, F" uniqKey="Cao F">F. Cao</name></author><author><name sortKey="Schreibmann, E" uniqKey="Schreibmann E">E. Schreibmann</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Wu, J C" uniqKey="Wu J">J.C. Wu</name></author><author><name sortKey="Xing, L" uniqKey="Xing L">L. Xing</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimitrakopoulou Strauss, A" uniqKey="Dimitrakopoulou Strauss A">A. Dimitrakopoulou-Strauss</name></author><author><name sortKey="Hohenberger, P" uniqKey="Hohenberger P">P. Hohenberger</name></author><author><name sortKey="Haberkorn, U" uniqKey="Haberkorn U">U. Haberkorn</name></author><author><name sortKey="Macke, H R" uniqKey="Macke H">H.R. Macke</name></author><author><name sortKey="Eisenhut, M" uniqKey="Eisenhut M">M. Eisenhut</name></author><author><name sortKey="Strauss, L G" uniqKey="Strauss L">L.G. Strauss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Pp, S" uniqKey="D Pp S">S. Däpp</name></author><author><name sortKey="Muller, C" uniqKey="Muller C">C. Müller</name></author><author><name sortKey="Garayoa, E G" uniqKey="Garayoa E">E.G. Garayoa</name></author><author><name sortKey="Bl Uenstein, P" uniqKey="Bl Uenstein P">P. Bläuenstein</name></author><author><name sortKey="Maes, V" uniqKey="Maes V">V. Maes</name></author><author><name sortKey="Brans, L" uniqKey="Brans L">L. Brans</name></author><author><name sortKey="Tourwe, D A" uniqKey="Tourwe D">D.A. Tourwé</name></author><author><name sortKey="Schibli, R" uniqKey="Schibli R">R. Schibli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wild, D" uniqKey="Wild D">D. Wild</name></author><author><name sortKey="Frischknecht, M" uniqKey="Frischknecht M">M. Frischknecht</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author><author><name sortKey="Morgenstern, A" uniqKey="Morgenstern A">A. Morgenstern</name></author><author><name sortKey="Bruchertseifer, F" uniqKey="Bruchertseifer F">F. Bruchertseifer</name></author><author><name sortKey="Boisclair, J" uniqKey="Boisclair J">J. Boisclair</name></author><author><name sortKey="Provencher Bolliger, A" uniqKey="Provencher Bolliger A">A. Provencher-Bolliger</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author><author><name sortKey="Maecke, H R" uniqKey="Maecke H">H.R. Maecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, C J" uniqKey="Smith C">C.J. Smith</name></author><author><name sortKey="Sieckman, G L" uniqKey="Sieckman G">G.L. Sieckman</name></author><author><name sortKey="Owen, N K" uniqKey="Owen N">N.K. Owen</name></author><author><name sortKey="Hayes, D L" uniqKey="Hayes D">D.L. Hayes</name></author><author><name sortKey="Mazuru, D G" uniqKey="Mazuru D">D.G. Mazuru</name></author><author><name sortKey="Volkert, W A" uniqKey="Volkert W">W.A. Volkert</name></author><author><name sortKey="Hoffman, T J" uniqKey="Hoffman T">T.J. Hoffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lantry, L E" uniqKey="Lantry L">L.E. Lantry</name></author><author><name sortKey="Cappelletti, E" uniqKey="Cappelletti E">E. Cappelletti</name></author><author><name sortKey="Maddalena, M E" uniqKey="Maddalena M">M.E. Maddalena</name></author><author><name sortKey="Fox, J S" uniqKey="Fox J">J.S. Fox</name></author><author><name sortKey="Feng, W" uniqKey="Feng W">W. Feng</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Thomas, R" uniqKey="Thomas R">R. Thomas</name></author><author><name sortKey="Eaton, S M" uniqKey="Eaton S">S.M. Eaton</name></author><author><name sortKey="Bogdan, N J" uniqKey="Bogdan N">N.J. Bogdan</name></author><author><name sortKey="Arunachalam, T" uniqKey="Arunachalam T">T. Arunachalam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koumarianou, E" uniqKey="Koumarianou E">E. Koumarianou</name></author><author><name sortKey="Mikolajczak, R" uniqKey="Mikolajczak R">R. Mikołajczak</name></author><author><name sortKey="Pawlak, D" uniqKey="Pawlak D">D. Pawlak</name></author><author><name sortKey="Zikos, X" uniqKey="Zikos X">X. Zikos</name></author><author><name sortKey="Bouziotis, P" uniqKey="Bouziotis P">P. Bouziotis</name></author><author><name sortKey="Garnuszek, P" uniqKey="Garnuszek P">P. Garnuszek</name></author><author><name sortKey="Karczmarczyk, U" uniqKey="Karczmarczyk U">U. Karczmarczyk</name></author><author><name sortKey="Maurin, M" uniqKey="Maurin M">M. Maurin</name></author><author><name sortKey="Archimandritis, S C" uniqKey="Archimandritis S">S.C. Archimandritis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nock, B" uniqKey="Nock B">B. Nock</name></author><author><name sortKey="Nikolopoulou, A" uniqKey="Nikolopoulou A">A. Nikolopoulou</name></author><author><name sortKey="Chiotellis, E" uniqKey="Chiotellis E">E. Chiotellis</name></author><author><name sortKey="Loudos, G" uniqKey="Loudos G">G. Loudos</name></author><author><name sortKey="Maintas, D" uniqKey="Maintas D">D. Maintas</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author><author><name sortKey="Maina, T" uniqKey="Maina T">T. Maina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abiraj, K" uniqKey="Abiraj K">K. Abiraj</name></author><author><name sortKey="Mansi, R" uniqKey="Mansi R">R. Mansi</name></author><author><name sortKey="Tamma, M L" uniqKey="Tamma M">M.L. Tamma</name></author><author><name sortKey="Fani, M" uniqKey="Fani M">M. Fani</name></author><author><name sortKey="Forrer, F" uniqKey="Forrer F">F. Forrer</name></author><author><name sortKey="Nicolas, G" uniqKey="Nicolas G">G. Nicolas</name></author><author><name sortKey="Cescato, R" uniqKey="Cescato R">R. Cescato</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author><author><name sortKey="Maecke, H R" uniqKey="Maecke H">H.R. Maecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cescato, R" uniqKey="Cescato R">R. Cescato</name></author><author><name sortKey="Maina, T" uniqKey="Maina T">T. Maina</name></author><author><name sortKey="Nock, B" uniqKey="Nock B">B. Nock</name></author><author><name sortKey="Nikolopoulou, A" uniqKey="Nikolopoulou A">A. Nikolopoulou</name></author><author><name sortKey="Charalambidis, D" uniqKey="Charalambidis D">D. Charalambidis</name></author><author><name sortKey="Piccand, V" uniqKey="Piccand V">V. Piccand</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mansi, R" uniqKey="Mansi R">R. Mansi</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Forrer, F" uniqKey="Forrer F">F. Forrer</name></author><author><name sortKey="Kneifel, S" uniqKey="Kneifel S">S. Kneifel</name></author><author><name sortKey="Tamma, M L" uniqKey="Tamma M">M.L. Tamma</name></author><author><name sortKey="Waser, B" uniqKey="Waser B">B. Waser</name></author><author><name sortKey="Cescato, R" uniqKey="Cescato R">R. Cescato</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author><author><name sortKey="Maecke, H R" uniqKey="Maecke H">H.R. Maecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dumont, R A" uniqKey="Dumont R">R.A. Dumont</name></author><author><name sortKey="Tamma, M" uniqKey="Tamma M">M. Tamma</name></author><author><name sortKey="Braun, F" uniqKey="Braun F">F. Braun</name></author><author><name sortKey="Borkowski, S" uniqKey="Borkowski S">S. Borkowski</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author><author><name sortKey="Maecke, H" uniqKey="Maecke H">H. Maecke</name></author><author><name sortKey="Weber, W A" uniqKey="Weber W">W.A. Weber</name></author><author><name sortKey="Mansi, R" uniqKey="Mansi R">R. Mansi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chatalic, K L" uniqKey="Chatalic K">K.L. Chatalic</name></author><author><name sortKey="Konijnenberg, M" uniqKey="Konijnenberg M">M. Konijnenberg</name></author><author><name sortKey="Nonnekens, J" uniqKey="Nonnekens J">J. Nonnekens</name></author><author><name sortKey="De Blois, E" uniqKey="De Blois E">E. de Blois</name></author><author><name sortKey="Hoeben, S" uniqKey="Hoeben S">S. Hoeben</name></author><author><name sortKey="De Ridder, C" uniqKey="De Ridder C">C. de Ridder</name></author><author><name sortKey="Brunel, L" uniqKey="Brunel L">L. Brunel</name></author><author><name sortKey="Fehrentz, J A" uniqKey="Fehrentz J">J.A. Fehrentz</name></author><author><name sortKey="Martinez, J" uniqKey="Martinez J">J. Martinez</name></author><author><name sortKey="Van Gent, D C" uniqKey="Van Gent D">D.C. van Gent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nock, B A" uniqKey="Nock B">B.A. Nock</name></author><author><name sortKey="Kaloudi, A" uniqKey="Kaloudi A">A. Kaloudi</name></author><author><name sortKey="Lymperis, E" uniqKey="Lymperis E">E. Lymperis</name></author><author><name sortKey="Giarika, A" uniqKey="Giarika A">A. Giarika</name></author><author><name sortKey="Kulkarni, H R" uniqKey="Kulkarni H">H.R. Kulkarni</name></author><author><name sortKey="Klette, I" uniqKey="Klette I">I. Klette</name></author><author><name sortKey="Singh, A" uniqKey="Singh A">A. Singh</name></author><author><name sortKey="Krenning, E P" uniqKey="Krenning E">E.P. Krenning</name></author><author><name sortKey="De Jong, M" uniqKey="De Jong M">M. de Jong</name></author><author><name sortKey="Maina, T" uniqKey="Maina T">T. Maina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author><author><name sortKey="Mume, E" uniqKey="Mume E">E. Mume</name></author><author><name sortKey="Sjoberg, S" uniqKey="Sjoberg S">S. Sjöberg</name></author><author><name sortKey="Frejd, F Y" uniqKey="Frejd F">F.Y. Frejd</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindbo, S" uniqKey="Lindbo S">S. Lindbo</name></author><author><name sortKey="Garousi, J" uniqKey="Garousi J">J. Garousi</name></author><author><name sortKey="Mitran, B" uniqKey="Mitran B">B. Mitran</name></author><author><name sortKey="Altai, M" uniqKey="Altai M">M. Altai</name></author><author><name sortKey="Buijs, J" uniqKey="Buijs J">J. Buijs</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author><author><name sortKey="Hober, S" uniqKey="Hober S">S. Hober</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilbur, S" uniqKey="Wilbur S">S. Wilbur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Llinares, M" uniqKey="Llinares M">M. Llinares</name></author><author><name sortKey="Devin, C" uniqKey="Devin C">C. Devin</name></author><author><name sortKey="Chaloin, O" uniqKey="Chaloin O">O. Chaloin</name></author><author><name sortKey="Azay, J" uniqKey="Azay J">J. Azay</name></author><author><name sortKey="Noel Artis, A M" uniqKey="Noel Artis A">A.M. Noel-Artis</name></author><author><name sortKey="Bernad, N" uniqKey="Bernad N">N. Bernad</name></author><author><name sortKey="Fehrentz, J A" uniqKey="Fehrentz J">J.A. Fehrentz</name></author><author><name sortKey="Martinez, J" uniqKey="Martinez J">J. Martinez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varasteh, Z" uniqKey="Varasteh Z">Z. Varasteh</name></author><author><name sortKey="Velikyan, I" uniqKey="Velikyan I">I. Velikyan</name></author><author><name sortKey="Lindeberg, G" uniqKey="Lindeberg G">G. Lindeberg</name></author><author><name sortKey="Sorensen, J" uniqKey="Sorensen J">J. Sörensen</name></author><author><name sortKey="Larhed, M" uniqKey="Larhed M">M. Larhed</name></author><author><name sortKey="Sandstrom, M" uniqKey="Sandstrom M">M. Sandström</name></author><author><name sortKey="Selvaraju, R K" uniqKey="Selvaraju R">R.K. Selvaraju</name></author><author><name sortKey="Malmberg, J" uniqKey="Malmberg J">J. Malmberg</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varasteh, Z" uniqKey="Varasteh Z">Z. Varasteh</name></author><author><name sortKey="Rosenstrom, U" uniqKey="Rosenstrom U">U. Rosenström</name></author><author><name sortKey="Velikyan, I" uniqKey="Velikyan I">I. Velikyan</name></author><author><name sortKey="Mitran, B" uniqKey="Mitran B">B. Mitran</name></author><author><name sortKey="Altai, M" uniqKey="Altai M">M. Altai</name></author><author><name sortKey="Honarvar, H" uniqKey="Honarvar H">H. Honarvar</name></author><author><name sortKey="Rosestedt, M" uniqKey="Rosestedt M">M. Rosestedt</name></author><author><name sortKey="Lindeberg, G" uniqKey="Lindeberg G">G. Lindeberg</name></author><author><name sortKey="Sorensen, J" uniqKey="Sorensen J">J. Sörensen</name></author><author><name sortKey="Larhed, M" uniqKey="Larhed M">M. Larhed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varasteh, Z" uniqKey="Varasteh Z">Z. Varasteh</name></author><author><name sortKey="Mitran, B" uniqKey="Mitran B">B. Mitran</name></author><author><name sortKey="Rosenstrom, U" uniqKey="Rosenstrom U">U. Rosenström</name></author><author><name sortKey="Velikyan, I" uniqKey="Velikyan I">I. Velikyan</name></author><author><name sortKey="Rosestedt, M" uniqKey="Rosestedt M">M. Rosestedt</name></author><author><name sortKey="Lindeberg, G" uniqKey="Lindeberg G">G. Lindeberg</name></author><author><name sortKey="Sorensen, J" uniqKey="Sorensen J">J. Sörensen</name></author><author><name sortKey="Larhed, M" uniqKey="Larhed M">M. Larhed</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varasteh, Z" uniqKey="Varasteh Z">Z. Varasteh</name></author><author><name sortKey="Aberg, O" uniqKey="Aberg O">O. Aberg</name></author><author><name sortKey="Velikyan, I" uniqKey="Velikyan I">I. Velikyan</name></author><author><name sortKey="Lindeberg, G" uniqKey="Lindeberg G">G. Lindeberg</name></author><author><name sortKey="Sorensen, J" uniqKey="Sorensen J">J. Sörensen</name></author><author><name sortKey="Larhed, M" uniqKey="Larhed M">M. Larhed</name></author><author><name sortKey="Antoni, G" uniqKey="Antoni G">G. Antoni</name></author><author><name sortKey="Sandstrom, M" uniqKey="Sandstrom M">M. Sandström</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitran, B" uniqKey="Mitran B">B. Mitran</name></author><author><name sortKey="Thisgaard, H" uniqKey="Thisgaard H">H. Thisgaard</name></author><author><name sortKey="Rosenstrom, U" uniqKey="Rosenstrom U">U. Rosenström</name></author><author><name sortKey="Dam, J H" uniqKey="Dam J">J.H. Dam</name></author><author><name sortKey="Larhed, M" uniqKey="Larhed M">M. Larhed</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitran, B" uniqKey="Mitran B">B. Mitran</name></author><author><name sortKey="Rinne, S S" uniqKey="Rinne S">S.S. Rinne</name></author><author><name sortKey="Konijnenberg, M W" uniqKey="Konijnenberg M">M.W. Konijnenberg</name></author><author><name sortKey="Maina, T" uniqKey="Maina T">T. Maina</name></author><author><name sortKey="Nock, B A" uniqKey="Nock B">B.A. Nock</name></author><author><name sortKey="Altai, M" uniqKey="Altai M">M. Altai</name></author><author><name sortKey="Vorobyeva, A" uniqKey="Vorobyeva A">A. Vorobyeva</name></author><author><name sortKey="Larhed, M" uniqKey="Larhed M">M. Larhed</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author><author><name sortKey="De Jong, M" uniqKey="De Jong M">M. de Jong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moody, T W" uniqKey="Moody T">T.W. Moody</name></author><author><name sortKey="Crawley, J N" uniqKey="Crawley J">J.N. Crawley</name></author><author><name sortKey="Jensen, R T" uniqKey="Jensen R">R.T. Jensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biddlecombe, G B" uniqKey="Biddlecombe G">G.B. Biddlecombe</name></author><author><name sortKey="Rogers, B E" uniqKey="Rogers B">B.E. Rogers</name></author><author><name sortKey="De Visser, M" uniqKey="De Visser M">M. de Visser</name></author><author><name sortKey="Parry, J J" uniqKey="Parry J">J.J. Parry</name></author><author><name sortKey="De Jong, M" uniqKey="De Jong M">M. de Jong</name></author><author><name sortKey="Erion, J L" uniqKey="Erion J">J.L. Erion</name></author><author><name sortKey="Lewis, J S" uniqKey="Lewis J">J.S. Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffman, T J" uniqKey="Hoffman T">T.J. Hoffman</name></author><author><name sortKey="Gali, H" uniqKey="Gali H">H. Gali</name></author><author><name sortKey="Smith, C J" uniqKey="Smith C">C.J. Smith</name></author><author><name sortKey="Sieckman, G L" uniqKey="Sieckman G">G.L. Sieckman</name></author><author><name sortKey="Hayes, D L" uniqKey="Hayes D">D.L. Hayes</name></author><author><name sortKey="Owen, N K" uniqKey="Owen N">N.K. Owen</name></author><author><name sortKey="Volkert, W A" uniqKey="Volkert W">W.A. Volkert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitran, B" uniqKey="Mitran B">B. Mitran</name></author><author><name sortKey="Varasteh, Z" uniqKey="Varasteh Z">Z. Varasteh</name></author><author><name sortKey="Selvaraju, R K" uniqKey="Selvaraju R">R.K. Selvaraju</name></author><author><name sortKey="Lindeberg, G" uniqKey="Lindeberg G">G. Lindeberg</name></author><author><name sortKey="Sorensen, J" uniqKey="Sorensen J">J. Sörensen</name></author><author><name sortKey="Larhed, M" uniqKey="Larhed M">M. Larhed</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author><author><name sortKey="Rosenstrom, U" uniqKey="Rosenstrom U">U. Rosenström</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laznicek, M" uniqKey="Laznicek M">M. Láznícek</name></author><author><name sortKey="Kv Tina, J" uniqKey="Kv Tina J">J. Kvĕtina</name></author><author><name sortKey="Mazak, J" uniqKey="Mazak J">J. Mazák</name></author><author><name sortKey="Krch, V" uniqKey="Krch V">V. Krch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="W Llberg, H" uniqKey="W Llberg H">H. Wållberg</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maddalena, M E" uniqKey="Maddalena M">M.E. Maddalena</name></author><author><name sortKey="Fox, J" uniqKey="Fox J">J. Fox</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Feng, W" uniqKey="Feng W">W. Feng</name></author><author><name sortKey="Cagnolini, A" uniqKey="Cagnolini A">A. Cagnolini</name></author><author><name sortKey="Linder, K E" uniqKey="Linder K">K.E. Linder</name></author><author><name sortKey="Tweedle, M F" uniqKey="Tweedle M">M.F. Tweedle</name></author><author><name sortKey="Nunn, A D" uniqKey="Nunn A">A.D. Nunn</name></author><author><name sortKey="Lantry, L E" uniqKey="Lantry L">L.E. Lantry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grady, E F" uniqKey="Grady E">E.F. Grady</name></author><author><name sortKey="Slice, L W" uniqKey="Slice L">L.W. Slice</name></author><author><name sortKey="Brant, W O" uniqKey="Brant W">W.O. Brant</name></author><author><name sortKey="Walsh, J H" uniqKey="Walsh J">J.H. Walsh</name></author><author><name sortKey="Payan, D G" uniqKey="Payan D">D.G. Payan</name></author><author><name sortKey="Bunnett, N W" uniqKey="Bunnett N">N.W. Bunnett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="La Bella, R" uniqKey="La Bella R">R. La Bella</name></author><author><name sortKey="Garcia Garayoa, E" uniqKey="Garcia Garayoa E">E. Garcia-Garayoa</name></author><author><name sortKey="Bahler, M" uniqKey="Bahler M">M. Bahler</name></author><author><name sortKey="Bl Uenstein, P" uniqKey="Bl Uenstein P">P. Bläuenstein</name></author><author><name sortKey="Schibli, R" uniqKey="Schibli R">R. Schibli</name></author><author><name sortKey="Conrath, P" uniqKey="Conrath P">P. Conrath</name></author><author><name sortKey="Tourwe, D" uniqKey="Tourwe D">D. Tourwé</name></author><author><name sortKey="Schubiger, P A" uniqKey="Schubiger P">P.A. Schubiger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Garayoa, E" uniqKey="Garcia Garayoa E">E. García Garayoa</name></author><author><name sortKey="Schweinsberg, C" uniqKey="Schweinsberg C">C. Schweinsberg</name></author><author><name sortKey="Maes, V" uniqKey="Maes V">V. Maes</name></author><author><name sortKey="Ruegg, D" uniqKey="Ruegg D">D. Rüegg</name></author><author><name sortKey="Blanc, A" uniqKey="Blanc A">A. Blanc</name></author><author><name sortKey="Bl Uenstein, P" uniqKey="Bl Uenstein P">P. Bläuenstein</name></author><author><name sortKey="Tourwe, D A" uniqKey="Tourwe D">D.A. Tourwé</name></author><author><name sortKey="Beck Sickinger, A G" uniqKey="Beck Sickinger A">A.G. Beck-Sickinger</name></author><author><name sortKey="Schubiger, P A" uniqKey="Schubiger P">P.A. Schubiger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Waldherr, C" uniqKey="Waldherr C">C. Waldherr</name></author><author><name sortKey="Hinni, K" uniqKey="Hinni K">K. Hinni</name></author><author><name sortKey="Waser, B" uniqKey="Waser B">B. Waser</name></author><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author><author><name sortKey="Maecke, H R" uniqKey="Maecke H">H.R. Maecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Garayoa, E" uniqKey="Garcia Garayoa E">E. García Garayoa</name></author><author><name sortKey="Schweinsberg, C" uniqKey="Schweinsberg C">C. Schweinsberg</name></author><author><name sortKey="Maes, V" uniqKey="Maes V">V. Maes</name></author><author><name sortKey="Brans, L" uniqKey="Brans L">L. Brans</name></author><author><name sortKey="Bl Uenstein, P" uniqKey="Bl Uenstein P">P. Bläuenstein</name></author><author><name sortKey="Tourwe, D A" uniqKey="Tourwe D">D.A. Tourwe</name></author><author><name sortKey="Schibli, R" uniqKey="Schibli R">R. Schibli</name></author><author><name sortKey="Schubiger, P A" uniqKey="Schubiger P">P.A. Schubiger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sundberg, A L" uniqKey="Sundberg A">A.L. Sundberg</name></author><author><name sortKey="Steffen, A" uniqKey="Steffen A">A. Steffen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reubi, J C" uniqKey="Reubi J">J.C. Reubi</name></author><author><name sortKey="Erchegyi, J" uniqKey="Erchegyi J">J. Erchegyi</name></author><author><name sortKey="Cescato, R" uniqKey="Cescato R">R. Cescato</name></author><author><name sortKey="Waser, B" uniqKey="Waser B">B. Waser</name></author><author><name sortKey="Rivier, J E" uniqKey="Rivier J">J.E. Rivier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shipp, M A" uniqKey="Shipp M">M.A. Shipp</name></author><author><name sortKey="Tarr, G E" uniqKey="Tarr G">G.E. Tarr</name></author><author><name sortKey="Chen, C Y" uniqKey="Chen C">C.Y. Chen</name></author><author><name sortKey="Switzer, S N" uniqKey="Switzer S">S.N. Switzer</name></author><author><name sortKey="Hersh, L B" uniqKey="Hersh L">L.B. Hersh</name></author><author><name sortKey="Stein, H" uniqKey="Stein H">H. Stein</name></author><author><name sortKey="Sunday, M E" uniqKey="Sunday M">M.E. Sunday</name></author><author><name sortKey="Reinherz, E L" uniqKey="Reinherz E">E.L. Reinherz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roques, B P" uniqKey="Roques B">B.P. Roques</name></author><author><name sortKey="Noble, F" uniqKey="Noble F">F. Noble</name></author><author><name sortKey="Dauge, V" uniqKey="Dauge V">V. Dauge</name></author><author><name sortKey="Fournie Zaluski, M C" uniqKey="Fournie Zaluski M">M.C. Fournié-Zaluski</name></author><author><name sortKey="Beaumont, A" uniqKey="Beaumont A">A. Beaumont</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nock, B A" uniqKey="Nock B">B.A. Nock</name></author><author><name sortKey="Maina, T" uniqKey="Maina T">T. Maina</name></author><author><name sortKey="Krenning, E P" uniqKey="Krenning E">E.P. Krenning</name></author><author><name sortKey="De Jong, M" uniqKey="De Jong M">M. de Jong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wittendorf, R W" uniqKey="Wittendorf R">R.W. Wittendorf</name></author><author><name sortKey="Swagzdis, J E" uniqKey="Swagzdis J">J.E. Swagzdis</name></author><author><name sortKey="Gifford, R" uniqKey="Gifford R">R. Gifford</name></author><author><name sortKey="Mico, B A" uniqKey="Mico B">B.A. Mico</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decristoforo, C" uniqKey="Decristoforo C">C. Decristoforo</name></author><author><name sortKey="Mather, S J" uniqKey="Mather S">S.J. Mather</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Engfeldt, T" uniqKey="Engfeldt T">T. Engfeldt</name></author><author><name sortKey="Tran, T" uniqKey="Tran T">T. Tran</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author><author><name sortKey="Widstrom, C" uniqKey="Widstrom C">C. Widström</name></author><author><name sortKey="Feldwisch, J" uniqKey="Feldwisch J">J. Feldwisch</name></author><author><name sortKey="Abrahmsen, L" uniqKey="Abrahmsen L">L. Abrahmsen</name></author><author><name sortKey="Wennborg, A" uniqKey="Wennborg A">A. Wennborg</name></author><author><name sortKey="Karlstrom, A E" uniqKey="Karlstrom A">A.E. Karlström</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tran, T" uniqKey="Tran T">T. Tran</name></author><author><name sortKey="Engfeldt, T" uniqKey="Engfeldt T">T. Engfeldt</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author><author><name sortKey="Sandstrom, M" uniqKey="Sandstrom M">M. Sandström</name></author><author><name sortKey="Feldwisch, J" uniqKey="Feldwisch J">J. Feldwisch</name></author><author><name sortKey="Abrahmsen, L" uniqKey="Abrahmsen L">L. Abrahmsén</name></author><author><name sortKey="Wennborg, A" uniqKey="Wennborg A">A. Wennborg</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author><author><name sortKey="Karlstrom, A E" uniqKey="Karlstrom A">A.E. Karlström</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rusckowski, M" uniqKey="Rusckowski M">M. Rusckowski</name></author><author><name sortKey="Qu, T" uniqKey="Qu T">T. Qu</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S. Gupta</name></author><author><name sortKey="Ley, A" uniqKey="Ley A">A. Ley</name></author><author><name sortKey="Hnatowich, D J" uniqKey="Hnatowich D">D.J. Hnatowich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosik, D" uniqKey="Rosik D">D. Rosik</name></author><author><name sortKey="Thibblin, A" uniqKey="Thibblin A">A. Thibblin</name></author><author><name sortKey="Antoni, G" uniqKey="Antoni G">G. Antoni</name></author><author><name sortKey="Honarvar, H" uniqKey="Honarvar H">H. Honarvar</name></author><author><name sortKey="Strand, J" uniqKey="Strand J">J. Strand</name></author><author><name sortKey="Selvaraju, R K" uniqKey="Selvaraju R">R.K. Selvaraju</name></author><author><name sortKey="Altai, M" uniqKey="Altai M">M. Altai</name></author><author><name sortKey="Orlova, A" uniqKey="Orlova A">A. Orlova</name></author><author><name sortKey="Eriksson Karlstrom, A" uniqKey="Eriksson Karlstrom A">A. Eriksson Karlström</name></author><author><name sortKey="Tolmachev, V" uniqKey="Tolmachev V">V. Tolmachev</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Suède</li></country><region><li>East Middle Sweden</li><li>Svealand</li></region><settlement><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Oroujeni, Maryam" sort="Oroujeni, Maryam" uniqKey="Oroujeni M" first="Maryam" last="Oroujeni">Maryam Oroujeni</name></region><name sortKey="Abouzayed, Ayman" sort="Abouzayed, Ayman" uniqKey="Abouzayed A" first="Ayman" last="Abouzayed">Ayman Abouzayed</name><name sortKey="Lundmark, Fanny" sort="Lundmark, Fanny" uniqKey="Lundmark F" first="Fanny" last="Lundmark">Fanny Lundmark</name><name sortKey="Mitran, Bogdan" sort="Mitran, Bogdan" uniqKey="Mitran B" first="Bogdan" last="Mitran">Bogdan Mitran</name><name sortKey="Orlova, Anna" sort="Orlova, Anna" uniqKey="Orlova A" first="Anna" last="Orlova">Anna Orlova</name><name sortKey="Orlova, Anna" sort="Orlova, Anna" uniqKey="Orlova A" first="Anna" last="Orlova">Anna Orlova</name><name sortKey="Rosenstrom, Ulrika" sort="Rosenstrom, Ulrika" uniqKey="Rosenstrom U" first="Ulrika" last="Rosenström">Ulrika Rosenström</name><name sortKey="Tolmachev, Vladimir" sort="Tolmachev, Vladimir" uniqKey="Tolmachev V" first="Vladimir" last="Tolmachev">Vladimir Tolmachev</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000828 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000828 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6724035
|texte= Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31382362" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |